Promethazine Promethazine can be a phenothiazine spinoff, which differs structurally in the antipsychotic phenothiazines because of the presence of a branched aspect chain and no ring substitution.
Get clinical support right away for those who see any of the following: gradual/shallow respiration, intense drowsiness/difficulty waking up, confusion.
Epinephrine – Due to likely for promethazine to reverse epinephrine's vasopressor outcome, epinephrine really should not be applied to deal with hypotension connected with promethazine overdose.
Should you be prescribed this medication on a daily routine and pass up a dose, take it as soon as you bear in mind. Whether it is close to the time of another dose, skip the missed dose. Take your future dose within the common time. Will not double the dose to capture up.
Promethazine HCl and Codeine Phosphate Oral Resolution is indicated to the temporary aid of coughs and upper respiratory signs or symptoms associated with allergy or perhaps the prevalent chilly in people 18 a long time of age and more mature.
Clinical research of promethazine hydrochloride and codeine phosphate syrup didn't include things like adequate figures of subjects aged 65 and about to ascertain whether or not they react in another way from more youthful subjects. Other reported medical experience has not discovered dissimilarities in responses involving the aged and young sufferers.
Neuroleptic malignant syndrome (NMS) which may result in Dying. Let you know Health care provider immediately Should you have any of the following indicators of NMS:
Although antihistamines have already been observed to provide fetal mortality in rodents, the pharmacological effects of histamine inside the rodent tend not to parallel These in person. There aren't any satisfactory and nicely-managed Promethazine codeine syrup research of promethazine in Expecting Females.
The mix of promethazine hydrochloride and codeine phosphate really should be utilized with warning in pediatric individuals 6 years and more mature (see Warnings-Use in Pediatric Clients).
Promethazine is metabolized with the liver to a number of inactive metabolites for example sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.
This is particularly critical for aged sufferers, who may very well be a lot more sensitive to the effects of soreness medicines. If a lot of of this medication is taken for many years, it might grow to be practice-forming (creating psychological or Bodily dependence) or bring about an overdose.
Don't flush medicines down the bathroom or pour them into a drain Except instructed to take action. Appropriately discard this product or service when it's expired or no more necessary. Speak to your pharmacist or regional squander disposal enterprise.
If anyone has overdosed and it has major signs or symptoms for example passing out or difficulties respiration, connect with 911. Normally, get in touch with a poison Regulate Centre without delay.
are Expecting or program to be Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Option can hurt your unborn child. See “What on earth is the most important information and facts I ought to understand about Promethazine Hydrochloride and Codeine Phosphate Oral Remedy?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and could potentially cause major Negative effects within your newborn including enhanced sleepiness, respiration complications (respiratory despair), and Demise. It isn't identified if promethazine can move into your breast milk.